Multiflow assay
WebMultiflow Computer, Inc., founded in April, 1984 near New Haven, Connecticut, USA, was a manufacturer and seller of minisupercomputer hardware and software embodying the … Web1 mar. 2024 · The in vitro MultiFlow DNA Damage assay multiplexes p53, γH2AX, phospho-histone H3, and polyploidization biomarkers into 1 flow cytometric analysis …
Multiflow assay
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http://www.accuflow.com/ WebFor these chemicals MultiFlow data will be useful in future research and hypothesis testing. Collectively, the results suggest the MultiFlow assay and associated data analysis …
Web27 ian. 2024 · Multiflow DNA damage assay The genotoxic MoA of TEMPO and its 3 derivatives was investigated by a method for evaluating multiple endpoints that are associated with DNA damage response pathways (MultiFlow DNA Damage Kit—p53, γ-H2AX, Phospho-Histone H3) according to the manufacturer’s manual (Litron … Web30 ian. 2024 · To improve the classification of aneugenic substances and determine their MOA, we developed and validated the TubulinTracker assay that uses a GFP-tagged tubulin reporter cell line to study...
WebCAN MultiFlow™ Assay. Toxicology Services. CAN MultiFlow™ Assay Flyer. DNA Barcode Assay. Cell Line Characterization - DNA Barcode Assay. DNA Barcode Assay Flyer. Big Blue® Transgenic Rodent Mutation Assay. BioReliance Toxicology Services: Big Blue® Transgenic Rodent Mutation (TRM) assay utilizes a novel transgenic animal model. Web7 mar. 2024 · 2.5 MultiFlow DNA damage assay Logarithmically growing TK6 cells were plated into 96-well plates at a density of 2.0 ± 0.25 × 10 5 cells/mL and exposed to 20 concentrations ( n = 1 well for each concentration) of each test article (four wells each for the vehicle control and each positive control).
WebThe assessment of the MultiFlow ® assay was performed as part of a ring trial designed to evaluate the performance and transferability of the “new” test system based on these mechanistic markers.
WebMultiFlow Aneugen Molecular Mechanism Assay: cell treatments The chemicals identified as exhibiting an aneugenic ( n = 25) or mixed ( n = 1) MoA were tested in a follow-up type assay designed to investigate tubulin binding versus Aurora kinase B inhibition activities. ibuprofen and doxycycline interactionWebThe in vitro MultiFlow® assay optimizes GLP assay designs to move your program efficiently toward regulatory approval, keeping your program costs and timelines on … ibuprofen and early pregnancyWebThis assay is used for scoring the frequency of mutant phenotype erythrocytes (RBCs) and mutant phenotype immature erythrocytes (reticulocytes, or RETs) by measuring the … ibuprofen and doxycyclineWeb23 ian. 2024 · This includes: the TGx-DDI transcriptomic biomarker (i.e., 64-gene expression signature to identify DNA damage-inducing (DDI) substances), the MicroFlow ® assay (i.e., a flow cytometry-based micronucleus (MN) test), and the MultiFlow ® assay (i.e., a multiplexed flow cytometry-based reporter assay that yields mode of action (MoA) … monday\u0027s 3cWeb28 ian. 2024 · This assay simultaneously assesses micronuclei and multiple additional cellular markers associated with genotoxicity. Acoustic dosing (≤ 2 mg) of compound is … monday\\u0027s 3fWeb27 oct. 2024 · When an apparent MN response required a confirmatory MultiFlow assay result for an overall positive result, assay specificity markedly improved: 8/8 non-genotoxicants were identified as such, and 21/22 metabolism arms performed according to expectations. Importantly, this was the case even for the potent apoptogens (e.g. CCCP, … monday\u0027s 3oWebMultiflow BlueScreen™ HC and GreenScreen® HC are high-throughput gene reporter assays, developed by Gentronix, which measure increased transcription of GADD45 … ibuprofen and drug test